The nicotinic acid receptor--a new mechanism for an old drug.

Journal article

CONTEXT: Non-esterified fatty acids in plasma originate from adipose tissue. Delivery of fatty acids to the liver provides the substrate for VLDL triglycerides. Insulin-sensitive organs, overburdened by high concentrations of non-esterified fatty acids, may develop resistance to insulin action. In addition, insulin secretion from pancreatic beta-cells may be impaired by long-standing elevation of concentrations of non-esterified fatty acid in plasma. Normally, such concentrations fluctuate o...

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Authors: Karpe, F; Frayn, K

• Publication status: Published
• Journal: Lancet
• Volume: 363
• Issue: 9424
• Pages: 1892-1894
• Publication date: 2004-06-01
• DOI: 10.1016/s0140-6736(04)16359-9
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Receptors, Nicotinic; Humans; Lipid Metabolism; Lipoproteins; Niacin; Signal Transduction; Hypolipidemic Agents; Adipose Tissue; Lipolysis; Animals; Insulin Resistance; Cardiovascular Diseases; Fatty Acids, Nonesterified