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Therapeutic treatment of arthritic mice with 15-deoxy Δ12,14-prostaglandin J2 (15d-PGJ2) ameliorates disease through the suppression of Th17 cells and the induction of CD4+CD25−FOXP3+ cells

Abstract:

The prostaglandin, 15-deoxy -prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ2 in an experimental model of arthritis. Daily administration of 15d-PGJ2 attenuated the severity of CIA, reducing the clinical score, pain, and edema. 15d-PGJ2 treatment was associated with a marked reductio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1155/2016/9626427

Authors


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Role:
Author
ORCID:
0000-0002-8435-0766
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Role:
Author
ORCID:
0000-0003-4472-365X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Role:
Author
ORCID:
0000-0002-0417-779X
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Role:
Author
ORCID:
0000-0003-3439-4266
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Role:
Author
ORCID:
0000-0003-1987-8369
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Fundação de Amparo à Pesquisa do Estado de São Paulo More from this funder
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Grant:
2013/08216-2
University of São Paulo NAP-DIN More from this funder
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Grant:
11.1.21625.01.0
Publisher:
Hindawi Publisher's website
Journal:
Mediators of Inflammation Journal website
Volume:
2016
Pages:
Article: 9626427
Publication date:
2016-10-31
Acceptance date:
2016-08-04
DOI:
EISSN:
1466-1861
ISSN:
0962-9351
Pubs id:
pubs:687571
URN:
uri:35cbcf0a-c251-4642-a281-c6fe1a87f297
UUID:
uuid:35cbcf0a-c251-4642-a281-c6fe1a87f297
Local pid:
pubs:687571
Language:
English

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