Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing.

Journal article

The evolution of hypertrophic cardiomyopathy (HCM) towards dilatation and hypokinesis is an increasingly recognized complication with a high incidence of adverse outcomes, including sudden cardiac death, requiring defibrillator implantation and cardiac transplantation. It is generally regarded as the irreversible 'burnt-out' end-stage manifestation of HCM. We report one of the first cases of profound regression of the dilated-hypokinetic state by the application of biventricular pacing and cardiac resynchronization therapy (CRT). Reviewing the literature on the role of pacing in HCM and the energetic rationale for CRT in HCM prompts us to suggest that further systematic studies are needed urgently to assess the role of CRT in HCM variants.

Authors: Ashrafian, H; Mason, M; Mitchell, A

• Publication status: Published
• Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
• Volume: 9
• Issue: 1
• Pages: 50-54
• Publication date: 2007-01-01
• DOI: 10.1093/europace/eul137
• EISSN: 1532-2092
• ISSN: 1099-5129
• Language: English
• Keywords: Heart Conduction System; Cardiomyopathy, Hypertrophic; Pacemaker, Artificial; Heart Ventricles; Adult; Electrocardiography; Cardiomyopathy, Dilated; Disease Progression; Humans; Female