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HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy

Abstract:
Background The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. Methods HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with CD4 <100 cells/l were enrolled (2-weeks post-ART for HIV-infected) and followed for 44-weeks. We evaluated the relationship between carotid femoral pulse wave velocity (cfPWV) and T-cell activation (HLADR+CD3... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/infdis/jiz015

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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Publication date:
2019-01-02
Acceptance date:
2019-01-09
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:955508
URN:
uri:356e8ee4-209c-4782-8708-db8edbd96fae
UUID:
uuid:356e8ee4-209c-4782-8708-db8edbd96fae
Local pid:
pubs:955508

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