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Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides

Abstract:

Capsules are surface layers of hydrated capsular polysaccharides (CPSs) produced by many bacteria. The human pathogen Salmonella enterica serovar Typhi produces "Vi antigen" CPS, which contributes to virulence. In a conserved strategy used by bacteria with diverse CPS structures, translocation of Vi antigen to the cell surface is driven by an ATP-binding cassette (ABC) transporter. These transporters are engaged in heterooligomeric complexes proposed to form an enclosed translocation conduit ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1801336115

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
ORCID:
0000-0001-6744-5061
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Canadian Institutes of Health Research More from this funder
Natural Science and Engineering Research Council of Canada More from this funder
Canada Research Chairs More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
21
Pages:
E4870-E4879
Publication date:
2018-05-07
Acceptance date:
2018-04-13
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:847390
URN:
uri:3567e6a8-5053-4b52-b136-1405b2cfd410
UUID:
uuid:3567e6a8-5053-4b52-b136-1405b2cfd410
Local pid:
pubs:847390

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