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Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors

Abstract:

Hepatitis C virus (HCV) genotype (gt) 3 is highly prevalent globally, with non‐gt3a subtypes common in Southeast Asia. Resistance‐associated substitutions (RASs) have been shown to play a role in treatment failure. However, the role of RASs in gt3 is not well understood. We report the prevalence of RASs in a cohort of direct‐acting antiviral treatment‐naive, gt3‐infected patients, including those with rarer subtypes, and evaluate the effect of these RASs on direct‐acting antivirals in vitro. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.29837

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Bonsall, D More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
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Funding agency for:
Magri, A
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Funding agency for:
Barnes, E
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Grant:
MR/K01532X/1– STOP-HCV Consortium
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Publisher:
American Association for the Study of Liver Diseases Publisher's website
Journal:
Hepatology Journal website
Volume:
69
Issue:
5
Pages:
1861-1872
Publication date:
2018-04-27
Acceptance date:
2018-02-03
DOI:
ISSN:
1527-3350
Pubs id:
pubs:824375
URN:
uri:3550765c-0435-4885-86dd-d228fa69f7ed
UUID:
uuid:3550765c-0435-4885-86dd-d228fa69f7ed
Local pid:
pubs:824375

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