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Journal article

Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity.

Abstract:

Lactoferrin (LF) is a key modulator of inflammatory response. Since bone and immune systems are genetically and functionally linked, we were interested to know if LF could influence bone remodeling. Bovine LF (bLF) inhibited in vitro bone resorbing activity (IC50, 200 microg/ml) in a rabbit mixed bone cell culture, consisting of authentic osteoclasts in an environment of osteoblast and stromal cells. Using human CD14 selected cells committed toward osteoclasts, bLF (10 microg/ml) stimulated c...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Biochemical and biophysical research communications
Volume:
296
Issue:
2
Pages:
261-266
Publication date:
2002-08-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:35373c44-2efa-4d2d-b187-a0bd0771acff
Source identifiers:
103831
Local pid:
pubs:103831

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