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Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

Abstract:

Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy but there are no efficacy data for the leading candidate vaccine being considered for widespread use. To address this knowledge gap, we assessed the efficacy of a Vi-tetanus toxoid conjugate vaccine using an ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/s0140-6736(17)32149-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
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Grant:
*Grant Number Example*
Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
390
Issue:
10111
Pages:
2472-2480
Publication date:
2017-09-28
Acceptance date:
2017-07-26
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:732517
URN:
uri:3505598d-8d76-4c86-9edd-da7959f9ef81
UUID:
uuid:3505598d-8d76-4c86-9edd-da7959f9ef81
Local pid:
pubs:732517
Language:
English
Keywords:

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