Molecular epidemiology of the thalassaemias (including haemoglobin E).

Journal article

The thalassaemias are the most common genetic disorders of man, and over the last decade the molecular epidemiology of these defects has been studied in detail. After briefly reviewing the great diversity of mutations giving rise to these conditions, four global regions are discussed in more detail. The thalassaemias, of which haemoglobin E is one, are most frequent in Asia, where recent work has defined the molecular basis of the beta thalassaemias and the frequencies of the various types of...

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Authors: Hill, A

• Publication status: Published
• Journal: Bailliere's clinical haematology
• Volume: 5
• Issue: 1
• Pages: 209-238
• Publication date: 1992-01-01
• DOI: 10.1016/S0950-3536(11)80042-9
• ISSN: 0950-3536
• Language: English
• Keywords: Asia; Case-Control Studies; Hemoglobins, Abnormal; Globins; Hemoglobin E; Cluster Analysis; Thalassemia; Pacific Islands; Humans; Gene Frequency; Chromosome Deletion; Malaria, Falciparum; Selection (Genetics); Genes; Genotype; Africa; Phenotype; Prenatal Diagnosis; Models, Genetic; Male; Female; Adult; Child; Pregnancy; Fetal Diseases; Mass Screening; Europe