Hypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines. We investigated the hypoxia transcriptome in primary human bladder cancer using cDNA microarrays to compare genes induced by hypoxia in vitro in bladder cancer cell line EJ28 with genes upregulated in 39 bladder tumour specimens (27 superficial and 12 invasive). We correlated array mRNA fold changes with carbonic anhydra...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record