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Journal article

Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.

Abstract:

Hypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines. We investigated the hypoxia transcriptome in primary human bladder cancer using cDNA microarrays to compare genes induced by hypoxia in vitro in bladder cancer cell line EJ28 with genes upregulated in 39 bladder tumour specimens (27 superficial and 12 invasive). We correlated array mRNA fold changes with carbonic anhydra...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6602666

Authors


Journal:
British journal of cancer
Volume:
93
Issue:
3
Pages:
346-354
Publication date:
2005-08-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:34e12c8c-50a7-4fb8-9fc7-1bc7efcae5d2
Source identifiers:
244835
Local pid:
pubs:244835

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