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Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection.

Abstract:

Acquisition of non-sterilizing natural immunity to Plasmodium falciparum malaria has been shown in low transmission areas following multiple exposures. However, conflicting data from endemic areas suggest that the parasite may interfere with the induction of effective B-cell responses. To date, the impact of blood-stage parasite exposure on antigen-specific B cells has not been reported following controlled human malaria infection (CHMI). Here we analysed human B-cell responses in a series of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imm.12226

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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European Malaria Vaccine Development Association More from this funder
National Institute of Health Research More from this funder
European Commission More from this funder
Publisher:
Wiley Publisher's website
Journal:
Immunology Journal website
Volume:
141
Issue:
4
Pages:
628-644
Publication date:
2014-04-01
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
Source identifiers:
441719

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