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Journal article

Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.

Abstract:

The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism for T-cell failure. HLA-B*08 was recently identified as one HLA class I allele associated with spontaneous clearance of HCV replication. Selection of escape mutations in the immunodominant HLA-B*08-restricted epitope H...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00997-08

Authors


Salloum, S More by this author
Oniangue-Ndza, C More by this author
Neumann-Haefelin, C More by this author
Giugliano, S More by this author
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Journal:
Journal of virology
Volume:
82
Issue:
23
Pages:
11803-11812
Publication date:
2008-12-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:347e9aae-faf0-4a1e-ba70-85024a25602a
Source identifiers:
24450
Local pid:
pubs:24450

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