Survival trends in hematological malignancies in the Nordic countries through 50 years

Journal article

Compounds with a heterocyclic isoxazole ring are well known for their diverse biologic activities encompassing antimicrobial, antipsychotic, immunosuppressive, antidiabetic and anticancer effects. Recent studies on hematological malignancies have also shown that some of the isoxazole-derived compounds feature encouraging cancer selectivity, low toxicity to normal cells and ability to overcome cancer drug resistance of conventional treatments. These characteristics are particularly promising because patients with hematological malignancies face poor clinical outcomes caused by cancer drug resistance or relapse of the disease. This review summarizes the knowledge on isoxazole-derived compounds toward hematological malignancies and provides clues on their mechanism(s) of action (apoptosis, cell cycle arrest, ROS production) and putative pharmacological targets (c-Myc, BET, ATR, FLT3, HSP90, CARM1, tubulin, PD-1/PD-L1, HDACs) wherever known

Authors: Hemminki, K; Hemminki, J; Försti, A; Sud, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: Blood Cancer Journal
• Volume: 12
• Issue: 11
• Pages: 150-150
• Publication date: 2022-11-07
• DOI: 10.1038/s41408-022-00728-z
• EISSN: 2044-5385
• ISSN: 2044-5385
• Language: English
• Keywords: MEDLINE; Law; Internal medicine; Hematologic Neoplasms; Political science; Medicine; Hematology; Cancer; Immunology