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Sodium-glucose cotransporter-2 inhibitors and major adverse cardiovascular outcomes: a SMART-C collaborative meta-analysis

Abstract:

BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) consistently improve heart failure and kidney-related outcomes; however, effects on major adverse cardiovascular events (MACE) across different patient populations are less clear.

METHODS: This was a collaborative trial-level meta-analysis from the SGLT2i Meta-analysis Cardio-Renal Trialists Consortium, which includes all phase 3, placebo-controlled, outcomes trials of SGLT2i ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circulationaha.124.069568

Authors

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Role:
Author
ORCID:
0000-0002-4637-4361
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Role:
Author
ORCID:
0000-0002-6272-0666
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Role:
Author
ORCID:
0000-0001-9276-8380
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Role:
Author
ORCID:
0000-0002-0805-8683


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Grant:
2026621
Programme:
Emerging Leader Investigator Grant


Publisher:
American Heart Association
Journal:
Circulation More from this journal
Volume:
149
Issue:
23
Pages:
1789-1801
Publication date:
2024-04-07
Acceptance date:
2024-03-30
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pmid:
38583093


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