- Abstract:
-
Hypoxia-inducible factor (HIF) is an alpha,beta-heterodimeric transcription factor that mediates cellular responses to low oxygen concentration via the transcriptional activation of specific genes involved in both tumorogenesis and angiogenesis. Manipulation of the HIF pathway has potential use for the treatment of ischemic disease and cancer. Unlike HIF-beta, which is constitutively expressed, the levels and activity of the HIF-alpha subunit are regulated by processes involving posttranslati...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s1359-6446(04)03202-7
-
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- Journal:
- Drug discovery today
- Volume:
- 9
- Issue:
- 16
- Pages:
- 704-711
- Publication date:
- 2004-08-05
- DOI:
- EISSN:
-
1878-5832
- ISSN:
-
1359-6446
- URN:
-
uuid:3418e3e7-5791-41d7-8b1e-df7066e69595
- Source identifiers:
-
32832
- Local pid:
- pubs:32832
- Copyright date:
- 2004
Journal article
The HIF pathway as a therapeutic target.
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