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Journal article

The HIF pathway as a therapeutic target.

Abstract:

Hypoxia-inducible factor (HIF) is an alpha,beta-heterodimeric transcription factor that mediates cellular responses to low oxygen concentration via the transcriptional activation of specific genes involved in both tumorogenesis and angiogenesis. Manipulation of the HIF pathway has potential use for the treatment of ischemic disease and cancer. Unlike HIF-beta, which is constitutively expressed, the levels and activity of the HIF-alpha subunit are regulated by processes involving posttranslati...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Drug discovery today
Volume:
9
Issue:
16
Pages:
704-711
Publication date:
2004-08-05
DOI:
EISSN:
1878-5832
ISSN:
1359-6446
URN:
uuid:3418e3e7-5791-41d7-8b1e-df7066e69595
Source identifiers:
32832
Local pid:
pubs:32832

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