Journal article
The HIF pathway as a therapeutic target.
- Abstract:
-
Hypoxia-inducible factor (HIF) is an alpha,beta-heterodimeric transcription factor that mediates cellular responses to low oxygen concentration via the transcriptional activation of specific genes involved in both tumorogenesis and angiogenesis. Manipulation of the HIF pathway has potential use for the treatment of ischemic disease and cancer. Unlike HIF-beta, which is constitutively expressed, the levels and activity of the HIF-alpha subunit are regulated by processes involving posttranslati...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1359-6446(04)03202-7
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Bibliographic Details
- Journal:
- Drug discovery today
- Volume:
- 9
- Issue:
- 16
- Pages:
- 704-711
- Publication date:
- 2004-08-01
- DOI:
- EISSN:
-
1878-5832
- ISSN:
-
1359-6446
- Source identifiers:
-
32832
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:32832
- UUID:
-
uuid:3418e3e7-5791-41d7-8b1e-df7066e69595
- Local pid:
- pubs:32832
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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