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The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.

Abstract:

Multiple myeloma (MM) is a plasma cell neoplasm that proceeds through a premalignant state of monoclonal gammopathy of unknown significance; however, the molecular events responsible for myelomagenesis remain uncharacterized. To identify cellular pathways deregulated in MM, we addressed that sumoylation is homologous to ubiquitination and results in the attachment of the ubiquitin-like protein Sumo onto target proteins. Sumoylation was markedly enhanced in MM patient lysates compared with nor...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Blood
Volume:
115
Issue:
14
Pages:
2827-2834
Publication date:
2010-04-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3418b0b1-f3a2-4d0f-b247-680c23d74346
Source identifiers:
370036
Local pid:
pubs:370036

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