Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.

Journal article

The effect of tumour necrosis factor (TNF alpha) antibodies on synovial cell interleukin-1 (IL-1) production was investigated in 7 patients with rheumatoid arthritis and in 7 with osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNF alpha antibody in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1 production was low, despite high concentrations of TNF alpha, and IL-1 production was not inhibited by anti-TNF alpha antibody. In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1, and anti-TNF alpha agents may be useful in treatment.

Authors: Brennan, F; Chantry, D; Jackson, A; Maini, R; Feldmann, M

• Publication status: Published
• Journal: Lancet
• Volume: 2
• Issue: 8657
• Pages: 244-247
• Publication date: 1989-07-01
• DOI: 10.1016/s0140-6736(89)90430-3
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Immune Sera; Adult; Cells, Cultured; Male; Tumor Necrosis Factor-alpha; Antilymphocyte Serum; Synovial Membrane; Humans; Female; Arthritis, Rheumatoid; Middle Aged; Osteoarthritis; Interleukin-1; Aged, 80 and over; Aged; Enzyme-Linked Immunosorbent Assay