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Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Abstract:

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were created by site-directed mutagenesis and assayed for their level of drug resistance. The coding sequence for dihydrofolate reductase (DHFR) from the malaria parasite Plasmodium falciparum was mutageniz...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0905922106

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
29
Pages:
12025-12030
Publication date:
2009-07-08
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:33f65417-bf34-480b-bc75-74214972d0d9
Source identifiers:
133507
Local pid:
pubs:133507

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