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Complement activation in patients with neuromyelitis optica

Abstract:

The role of complement has been demonstrated in experimental models of neuromyelitis optica (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with dis...

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Authors


Nytrova, P More by this author
Potlukova, E More by this author
Kemlink, D More by this author
Woodhall, M More by this author
Horakova, D More by this author
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Publisher:
Elsevier
Journal:
Journal of Neuroimmunology
Volume:
274
Issue:
1-2
Pages:
185-191
Publication date:
2014
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:33e43cdc-f9bd-465b-b869-d56b1250bfe2
Source identifiers:
484553
Local pid:
pubs:484553

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