Diverse mechanisms of IRF5 action in inflammatory responses

Journal article

Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory phenotype. We discuss IRF5 interactions with a wide range of transcriptional regulators that give rise to its diverse effects at the level of chromatin.

Authors: Khoyratty, T; Udalova, I

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: International Journal of Biochemistry and Cell Biology
• Volume: 99
• Pages: 38-42
• Publication date: 2018-03-22
• Acceptance date: 2018-03-16
• DOI: 10.1016/j.biocel.2018.03.012
• EISSN: 1878-5875
• ISSN: 1357-2725
• Pmid: 29578052
• Language: English
• Keywords: transcription; myeloid cells; inflammation; IRF5