Journal article
Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow
- Abstract:
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Background: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumour uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography (dPET), and study correlations between values of the blood flow-related parameter K1 obtained from fits of the models and an independent blood flow measure obtained from perfusion CT (pCT).
Methods: NSCLC patients had a 45 minute dynamic FMISO PET/CT scan followed by two static PET/CT acquisitions at two and four hours post-injection. Perfusion CT scanning was then performed consisting of a 45 second cine CT. Reversible and irreversible two-, three- and four-tissue compartment models were fitted to 30 time-activity-curves (TACs) obtained for 15 whole tumour structures in 9 patients, each imaged twice. Descriptions of the TACs provided by the models were compared using the Akaike and Bayesian information criteria (AIC and BIC) and leave-one-out cross-validation. The precision with which fitted model parameters estimated ground-truth uptake kinetics was determined using statistical simulation techniques. Blood flow from pCT was correlated with K1 from PET kinetic models in addition to FMISO uptake levels.
Results: An irreversible three-tissue compartment model provided the best description of whole tumour FMISO uptake time-courses according to AIC, BIC and cross-validation scores totaled across the TACs. The simulation study indicated that this model also provided more precise estimates of FMISO uptake kinetics than other two- and three-tissue models. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from pCT (Pearson r coefficient = 0.81). The correlation from the irreversible three-tissue model (r=0.81) was stronger than that from than K1 values obtained from fits of a two-tissue compartment model (r=0.68), or FMISO uptake levels in static images taken at time-points from tracer injection through to four hours later (maximum at two minutes, r=0.70).
Conclusions: Time-courses of whole tumour FMISO uptake by advanced stage NSCLC are described best by an irreversible three-tissue compartment model. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from perfusion CT (r=0.81).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.1186/s13550-018-0430-4
Authors
- Funding agency for:
- Higgins, G
- Fenwick, J
- Grant:
- C34326/A19590
- C17203
- Funding agency for:
- McGowan, D
- Grant:
- ICA-CL-2016-02-009
- Publisher:
- Springer Open
- Journal:
- EJNMMI Research More from this journal
- Volume:
- 8
- Article number:
- 73
- Publication date:
- 2018-08-01
- Acceptance date:
- 2018-07-21
- DOI:
- EISSN:
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2191-219X
- Keywords:
- Pubs id:
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pubs:890184
- UUID:
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uuid:33b569cf-c3fc-4772-b146-387dc241f4a6
- Local pid:
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pubs:890184
- Source identifiers:
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890184
- Deposit date:
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2018-07-22
- ARK identifier:
Terms of use
- Copyright holder:
- © McGowen, et al 2018
- Copyright date:
- 2018
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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