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Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.

Abstract:

Trimming of the N-glycans attached to the envelope proteins of hepatitis B virus (HBV) is required in different steps of the viral life cycle. Inhibition of the host enzymes alpha-glucosidases, involved in the endoplasmic reticulum (ER)-associated processing of the N-linked glycans, results in misfolding of the HBV envelope proteins, prevention of HBV secretion and accumulation of viral DNA within infected cells. However, the impact of these effects on HBV morphogenesis and infectivity of the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Grant:
Collaborative Research International Grant
Publisher:
Elsevier Publisher's website
Journal:
Antiviral Research Journal website
Volume:
76
Issue:
1
Pages:
30-37
Publication date:
2007-05-22
DOI:
EISSN:
1872-9096
ISSN:
0166-3542
URN:
uuid:33b38c87-7b62-44d1-a276-5458624bbd4f
Source identifiers:
100288
Local pid:
pubs:100288

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