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Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.

Abstract:

Secreted phospholipase A2 group X (sPLA(2)-X) is one of the most potent enzymes of the phospholipase A(2) lipolytic enzyme superfamily. Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis. We studied the role of sPLA(2)-X enzyme activity in vitro and in vivo, by generating sPLA(2)-X-overexpressing macrophages and transgenic mac...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m710584200

Authors


Ghesquiere, SA More by this author
Vergouwe, MN More by this author
van der Made, I More by this author
Gijbels, MJ More by this author
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Journal:
The Journal of biological chemistry
Volume:
283
Issue:
31
Pages:
21640-21648
Publication date:
2008-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:3389a8f2-b3bd-468f-8f79-a9304a58a8b2
Source identifiers:
9611
Local pid:
pubs:9611

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