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Journal article

Targeting extracellular pyrophosphates underpins the high selectivity of nisin.

Abstract:

The spread of infectious diseases and the increase in antibiotic resistance represent a life-threatening global development that calls for new approaches to control microorganisms. Of all potential targets, the essential and unique pathway of bacterial cell wall synthesis, targeted by the first known antibiotic penicillin, remains a perfect candidate for the development of new antibiotics. Here we show that the lantibiotic nisin exercises its antibacterial action by targeting peptidoglycan in...

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Publication status:
Published

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Publisher copy:
10.1096/fj.04-2358com

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
18
Issue:
15
Pages:
1862-1869
Publication date:
2004-12-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
100349
Language:
English
Keywords:
Pubs id:
pubs:100349
UUID:
uuid:33874bcf-8c10-4072-98fe-790a77494592
Local pid:
pubs:100349
Deposit date:
2012-12-19

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