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Association of hepatitis B surface antigen carriage with severe malaria in Gambian children.

Abstract:

Severe malaria is a major cause of childhood mortality in sub-Saharan Africa but the factors predisposing children to severe forms of malaria have not been fully elucidated. In a case-control study of over 1,200 Gambian children hepatitis B virus carriage was significantly increased amongst cases of severe malaria compared to matched controls. We suggest that this association may relate to impaired clearance of liver stage parasites in the presence of the reduced level of HLA class I antigen ...

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Publication status:
Published

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Publisher copy:
10.1038/nm0495-374

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Nature medicine
Volume:
1
Issue:
4
Pages:
374-375
Publication date:
1995-04-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:334f9974-e13a-415c-a085-293d3ef6dc8d
Source identifiers:
95399
Local pid:
pubs:95399

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