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The evolution of the host microbiome as an ecosystem on a leash.

Abstract:

The human body carries vast communities of microbes that provide many benefits. Our microbiome is complex and challenging to understand, but evolutionary theory provides a universal framework with which to analyse its biology and health impacts. Here we argue that to understand a given microbiome feature, such as colonization resistance, host nutrition or immune development, we must consider how hosts and symbionts evolve. Symbionts commonly evolve to compete within the host ecosystem, while ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nature23292

Authors


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Institution:
University of Oxford
Department:
Magdalen College
Schluter, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Rakoff-Nahoum, S More by this author
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Funding agency for:
Coyte, KZ
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
548
Pages:
43-51
Publication date:
2017-08-02
Acceptance date:
2017-06-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:713175
URN:
uri:33037829-9488-4894-9257-7c528986e1d8
UUID:
uuid:33037829-9488-4894-9257-7c528986e1d8
Local pid:
pubs:713175
Language:
English
Keywords:

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