A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.

Journal article

A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.

Authors: Tosh, K; Meisner, S; Siddiqui, MR; Balakrishnan, K; Ghei, S

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 186
• Issue: 8
• Pages: 1190-1193
• Publication date: 2002-10-01
• DOI: 10.1086/343806
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Chromosome Mapping; Leprosy; Genetic Predisposition to Disease; Microsatellite Repeats; Genetics, Population; Genetic Markers; Female; Male; Chromosomes, Human, Pair 20; Humans; India; Mycobacterium leprae