Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria.

Journal article

Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.

Authors: Supanaranond, W; Suputtamongkol, Y; Davis, T; Pukrittayakamee, S; Teja-Isavadharm, P

• Publication status: Published
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
• Volume: 91
• Issue: 6
• Pages: 694-696
• Publication date: 1997-01-01
• DOI: 10.1016/s0035-9203(97)90528-9
• EISSN: 1878-3503
• ISSN: 0035-9203
• Language: English
• Keywords: Adolescent; Adult; Malaria, Falciparum; Electrocardiography; Mefloquine; Antimalarials; Blood Pressure; Heart; Heart Rate; Drug Interactions; Quinine; Drug Therapy, Combination; Humans