Journal article icon

Journal article

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cells in vitro.

Abstract:

Carbonic anhydrase IX (CA IX) is a hypoxia-regulated enzyme, overexpressed in many types of human cancer. CA IX is involved in pH homeostasis, contributing to extracellular acidification and tumourigenesis. Acidification of the extracellular milieu can impact upon cellular uptake of chemotherapeutic drugs by favouring weak acids (e.g. melphalan), but limiting access of weak bases (e.g. doxorubicin). We investigated whether alterations of CA IX activity affected anti-cancer drug uptake and tox...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Publisher:
Informa Healthcare
Journal:
Journal of enzyme inhibition and medicinal chemistry
Volume:
28
Issue:
2
Pages:
360-369
Publication date:
2013-04-05
DOI:
EISSN:
1475-6374
ISSN:
1475-6366
URN:
uuid:32eb07ad-3cde-4ac7-bca0-14cf55070078
Source identifiers:
375121
Local pid:
pubs:375121

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP