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Subthalamic nucleotomy alleviates parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate.

Abstract:
Research into the neural mechanisms underlying the symptoms of parkinsonism utilizing the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate model have shown that the subthalamic nucleus (STN) occupies a central role. As a logical development of this theory, we have studied the effects of thermocoagulative lesions of the STN in the primate model. Such lesions can cause remarkable symptom reversal in the experimental primate model.
Publication status:
Published

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Publisher copy:
10.3109/02688699209002375

Authors


Agarwal, E More by this author
Sambrook, MA More by this author
Crossman, AR More by this author
Journal:
British journal of neurosurgery
Volume:
6
Issue:
6
Pages:
575-582
Publication date:
1992
DOI:
EISSN:
1360-046X
ISSN:
0268-8697
URN:
uuid:32d93a25-605e-4ae7-b78b-9b13505e6f35
Source identifiers:
252497
Local pid:
pubs:252497

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