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Entropic organization of interphase chromosomes

Abstract:

Chromosomes are not distributed randomly in nuclei. Appropriate positioning can activate (or repress) genes by bringing them closer to active (or inactive) compartments like euchromatin (or heterochromatin), and this is usually assumed to be driven by specific local forces (e.g., involving H bonds between nucleosomes or between nucleosomes and the lamina). Using Monte Carlo simulations, we demonstrate that nonspecific (entropic) forces acting alone are sufficient to position and shape self-av...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1083/jcb.200903083

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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
Role:
Author
More by this author
Institution:
University of Edinburgh
Department:
Scottish Universities Physics Alliance,School of Physics and Astronomy
Role:
Author
University of Edinburgh Compute and Data Facility More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
186
Issue:
6
Pages:
825-834
Publication date:
2009-09-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:32d374e1-5f12-4037-bae1-a73b59ec176a
Local pid:
ora:3775
Language:
English
Keywords:
Subjects:

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