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Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration

Abstract:
Background. Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is dependent on the continued high efficacy of praziquantel; however, drug efficacy is rarely monitored using appropriate statistical approaches that can detect early signs of wane. Methods. We conducted a repeated cross-sectional study, examining children infected with Schistosoma mansoni from 6... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciw506

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
B9 TROPICAL MEDICINE
Lamberton, PHL More by this author
Kabatereine, NB More by this author
Tukahebwa, EM More by this author
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Schistosomiasis Control Initiative More from this funder
UNICEF/UNDP/World Bank WHO Special Programme for Research More from this funder
Training in Tropical Disease More from this funder
Wellcome Trust More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
63
Issue:
9
Pages:
1151-1159
Publication date:
2016-07-28
Acceptance date:
2016-07-17
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:745482
URN:
uri:32bf86c6-46af-4cdd-888c-e08a70fbbaea
UUID:
uuid:32bf86c6-46af-4cdd-888c-e08a70fbbaea
Local pid:
pubs:745482

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