Journal article
The role of astrocyte dysfunction in Parkinson's disease pathogenesis
- Abstract:
- Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson's disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.9MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.tins.2017.04.001
Authors
- Publisher:
- Elsevier
- Journal:
- Trends in Neurosciences More from this journal
- Volume:
- 40
- Issue:
- 6
- Pages:
- 358-370
- Publication date:
- 2017-05-17
- DOI:
- EISSN:
-
1878-108X
- ISSN:
-
0166-2236
- Pmid:
-
28527591
- Language:
-
English
- Pubs id:
-
pubs:698083
- UUID:
-
uuid:32954908-586d-4e12-85cd-5c38b7d072a5
- Local pid:
-
pubs:698083
- Source identifiers:
-
698083
- Deposit date:
-
2018-02-02
- ARK identifier:
Terms of use
- Copyright holder:
- © 2017 Booth, Hirst, and Wade-Martins
- Copyright date:
- 2017
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record