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Towards the total synthesis of keramaphidin B

Abstract:
The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new synthetic strategy to the heavily functionalised piperidine core of keramaphidin B.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3762/bjoc.12.104

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


More from this funder
Funding agency for:
Jakubec, P
Farley, AJM
Dixon, DJ
Grant:
Post-Doctoral Fellowship
EP/M50659X/1
Leadership Fellowship


Publisher:
Beilstein-Institut
Journal:
Beilstein Journal of Organic Chemistry More from this journal
Volume:
12
Pages:
1096-1100
Publication date:
2016-05-30
Acceptance date:
2016-05-10
DOI:
ISSN:
1860-5397
Pmid:
27340496


Language:
English
Keywords:
Pubs id:
pubs:631390
UUID:
uuid:3272b95e-a1ad-42cf-9d25-71591191af52
Local pid:
pubs:631390
Source identifiers:
631390
Deposit date:
2016-09-06

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