Journal article
A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labelling in humans at 3 T
- Abstract:
-
Purpose
A novel method for quantitative measurement of Myocardial Blood Flow (MBF) using Arterial Spin Labelling (ASL) in a single breath hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability.
Methods
A Flow-sensitive Alternating Inversion Recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 T. Scans were performed on 10 healthy volunteers and MBF measured in three slices. The method was investigated for reproducibility by Bland-Altman analysis and statistical measures, the coefficients of reproducibility (CR) and variation (CV) are reported.
Results
The MBF values for the basal, mid and apical slices were 1.04 ± 0.40, 1.06 ± 0.46 and 1.06 ± 0.38 ml/g/min respectively (mean ± SD), which compare well with literature values. The CV across all scans, 43%, was greater than the between-session and within-session values, at 16 and 13% respectively, for the mid-ventricular slice. The change in MBF required for detection, from the coefficient of reproducibility, was 61% between-session and 53% within-session for the mid-ventricle.
Conclusion
This study shows the feasibility of the LL-FAIR-ASL method for the quantification of MBF. The statistical measures reported will allow the planning of future clinical research studies involving rest and stress measurements.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
- Publisher:
- Wiley
- Journal:
- Magnetic Resonance in Medicine More from this journal
- Publication date:
- 2016-09-08
- Acceptance date:
- 2016-07-28
- DOI:
- ISSN:
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0740-3194
Terms of use
- Copyright holder:
- Keith et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative CommonsAttribution 4.0 International,which permits unrestricted use,distribution and reproduction in any medium provided that the original work is properly attributed. Magnetic Resonance in Medicine published by WileyPeriodicals, Inc. on behalf of International Society for Magnetic Resonancein Medicine.
- Licence:
- CC Attribution (CC BY)
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