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Journal article

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.

Abstract:

HLA-B*57 is the class I allele most consistently associated with control of human immunodeficiency virus (HIV) replication, which may be linked to the specific HIV peptides that this allele presents to cytotoxic T lymphocytes (CTLs), and the resulting efficacy of these cellular immune responses. In two HIV C clade-infected populations in South Africa and Zambia, we sought to elucidate the role of HLA-B*5703 in HIV disease outcome. HLA-B*5703-restricted CTL responses select for escape mutation...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20081984

Authors


Crawford, H More by this author
Schaefer, M More by this author
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Journal:
The Journal of experimental medicine
Volume:
206
Issue:
4
Pages:
909-921
Publication date:
2009-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3269b569-92ca-4fa9-ae9e-16ff0246bb01
Source identifiers:
191235
Local pid:
pubs:191235

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