Large scale clinical trials: lessons from the COVID-19 pandemic

Journal article

Delivery of clinical trials, particularly earlier phase trials, in a pandemic clinical environment is highly challenging, and was reactive rather than anticipatory. Future pandemic studies should be designed and tested in advance, making use of pragmatic study designs as far as possible and planning for integration between early and later phase trials and regulatory frameworks.

Authors: Horsley, AR; Pearmain, L; Knight, S; Schindler, N; Wang, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BMJ Publishing Group
• Journal: BMJ Open Respiratory Research
• Volume: 9
• Issue: 1
• Pages: e001226-e001226
• Publication date: 2022-06-14
• Acceptance date: 2022-05-14
• DOI: 10.1136/bmjresp-2022-001226
• EISSN: 2052-4439
• ISSN: 2052-4439
• Language: English
• Keywords: Scale (ratio); Medicine; Medical education; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Clinical trial; Pathology; Disease; Pandemic; Thematic analysis; Qualitative research