- Abstract:
-
T cell receptor (TCR)-dependent regulatory T cell (Treg) activity controls effector T cell (Teff) function and is inhibited by the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Protein kinase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff activation. In contrast, PKC-theta was sequestered away from the Treg immunological synapse. Furthermore, PKC-theta blockade enhanced Treg function, demonstrating PKC-theta inhibits Treg-mediated suppr...
Expand abstract - Publisher copy:
- 10.1126/science.1186068
-
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- Journal:
- Science (New York, N.Y.)
- Volume:
- 328
- Issue:
- 5976
- Pages:
- 372-376
- Publication date:
- 2010-04-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- URN:
-
uuid:32400e24-974e-417e-854a-82ad4afa1289
- Source identifiers:
-
426285
- Local pid:
- pubs:426285
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Protein kinase C-theta mediates negative feedback on regulatory T cell function.
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