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Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Abstract:

T cell receptor (TCR)-dependent regulatory T cell (Treg) activity controls effector T cell (Teff) function and is inhibited by the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Protein kinase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff activation. In contrast, PKC-theta was sequestered away from the Treg immunological synapse. Furthermore, PKC-theta blockade enhanced Treg function, demonstrating PKC-theta inhibits Treg-mediated suppr...

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Publisher copy:
10.1126/science.1186068

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Journal:
Science (New York, N.Y.)
Volume:
328
Issue:
5976
Pages:
372-376
Publication date:
2010-04-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:32400e24-974e-417e-854a-82ad4afa1289
Source identifiers:
426285
Local pid:
pubs:426285

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