T cell receptor (TCR)-dependent regulatory T cell (Treg) activity controls effector T cell (Teff) function and is inhibited by the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Protein kinase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff activation. In contrast, PKC-theta was sequestered away from the Treg immunological synapse. Furthermore, PKC-theta blockade enhanced Treg function, demonstrating PKC-theta inhibits Treg-mediated suppr...Expand abstract
- Publisher copy:
- Copyright date:
Protein kinase C-theta mediates negative feedback on regulatory T cell function.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record