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Journal article

JCAD, a gene at the 10p11 coronary artery disease locus, regulates hippo signaling in endothelial cells

Abstract:
Objective— A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for most loci the underlying biological mechanism is unknown. Determining the molecular pathways and cellular processes affected by these loci will provide new insights into CAD pathophysiology and may lead to new therapies. The CAD-associated variants at 10p11.23 fall in JCAD, which encodes an endothelial junction protein... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1161/atvbaha.118.310976

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Role:
Author
ORCID:
0000-0002-6667-7562
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Grant:
Transatlantic Networks of Excellence Award (12CVD02)
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Grant:
Seventh Framework Programme FP7/2007-2013 under grant agreement number HEALTH-F2-2013-601456
National Institute for Health Research More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
Volume:
38
Issue:
8
Pages:
1711-1722
Publication date:
2018-05-24
Acceptance date:
2018-05-09
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Pubs id:
pubs:854319
URN:
uri:32315ebf-c207-4972-84d8-45354f53d471
UUID:
uuid:32315ebf-c207-4972-84d8-45354f53d471
Local pid:
pubs:854319

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