Journal article
JCAD, a gene at the 10p11 coronary artery disease locus, regulates hippo signaling in endothelial cells
- Abstract:
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Objective— A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for most loci the underlying biological mechanism is unknown. Determining the molecular pathways and cellular processes affected by these loci will provide new insights into CAD pathophysiology and may lead to new therapies. The CAD-associated variants at 10p11.23 fall in JCAD, which encodes an endothelial junction protein... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 2.9MB, Terms of use)
-
- Publisher copy:
- 10.1161/atvbaha.118.310976
Authors
Funding
+ European
Union
More from this funder
Grant:
Seventh Framework Programme FP7/2007-2013 under grant
agreement number HEALTH-F2-2013-601456
+ Leducq Foundation
More from this funder
Grant:
Transatlantic Networks of Excellence
Award (12CVD02
Bibliographic Details
- Publisher:
- American Heart Association
- Journal:
- Arteriosclerosis, Thrombosis, and Vascular Biology More from this journal
- Volume:
- 38
- Issue:
- 8
- Pages:
- 1711-1722
- Publication date:
- 2018-05-24
- Acceptance date:
- 2018-05-09
- DOI:
- EISSN:
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1524-4636
- ISSN:
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1079-5642
- Pmid:
-
29794114
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:854319
- UUID:
-
uuid:32315ebf-c207-4972-84d8-45354f53d471
- Local pid:
-
pubs:854319
- Source identifiers:
-
854319
- Deposit date:
-
2018-08-24
Terms of use
- Copyright holder:
- American Heart Association, Inc
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Heart Association, Inc. This is the accepted manuscript version of the article. The final version is available online from American Heart Association at: https://doi.org/10.1161/atvbaha.118.310976
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