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Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine.

Abstract:

Using positron emission tomography (PET) we previously showed that activation of the putamen, supplementary motor area, and cingulate cortex is impaired in patients with Parkinson's disease (PD) when they are off treatment and perform volitional motor tasks. Evidence suggests that these areas are involved in the generation of internally cued movements in normal subjects. We have now studied the effect of the dopamine agonist apomorphine on cerebral activation when used to treat the akinesia o...

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Publication status:
Published

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Publisher copy:
10.1002/ana.410320608

Authors


Jenkins, IH More by this author
Fernandez, W More by this author
Playford, ED More by this author
Frackowiak, RS More by this author
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Journal:
Annals of neurology
Volume:
32
Issue:
6
Pages:
749-757
Publication date:
1992-12-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:3217c50c-63b7-4d12-a94a-3df977d2a9cd
Source identifiers:
7327
Local pid:
pubs:7327

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