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Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins.

Abstract:

Natural killer (NK) cells secrete lytic granules to directly kill virus-infected or transformed cells and secrete cytokines to communicate with other cells. Three-dimensional super-resolved images of F-actin, lytic granules, and IFN-γ in primary human NK cells stimulated through different activating receptors reveal that both IFN-γ and lytic granules accumulated in domains where the periodicity of the cortical actin mesh at the synapse opened up to be penetrable. Ligation of some activating r...

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Publication status:
Published

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Authors


Dobbie, IM More by this author
Alakoskela, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Blood
Volume:
120
Issue:
18
Pages:
3729-3740
Publication date:
2012-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3208e9e8-2feb-4b8d-85e1-e059b7d7297e
Source identifiers:
350631
Local pid:
pubs:350631

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