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Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development.

Abstract:

Successful development of Plasmodium sexual stages is essential for parasite survival, but the genes involved are poorly understood. We 'knocked out' the male development gene-1 (mdv-1) locus in Plasmodium berghei and found it to be important in female gametocyte activation. Indirect immunofluorescence assays show MDV-1 has a punctate cytoplasmic distribution in gametocytes. After activation of both females and males, MDV-1 is more peripherally located but in males exclusively it becomes conc...

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Authors


Delves, MJ More by this author
Bromley, E More by this author
Wastling, JM More by this author
Tomley, FM More by this author
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Journal:
International journal for parasitology
Volume:
39
Issue:
7
Pages:
755-761
Publication date:
2009-06-05
DOI:
EISSN:
1879-0135
ISSN:
0020-7519
URN:
uuid:31f82be8-4f05-4208-8195-f8960d76ad68
Source identifiers:
265864
Local pid:
pubs:265864

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