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17,β‐estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle

Abstract:
Background & Aims Oestrogen and oestrogen‐mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of hepatitis C virus life cycle is/are affected by oestrogens. Methods Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β‐estradiol (tested with/without its receptor antagonist fulvestrant). Dose–response c... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/liv.13303

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Barbaglia, MN More by this author
Foglia, CZ More by this author
Boccato, E More by this author
Burlone, ME More by this author
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Publisher:
Wiley Publisher's website
Journal:
Liver International Journal website
Volume:
37
Issue:
5
Pages:
669-677
Publication date:
2016-11-25
Acceptance date:
2016-10-31
DOI:
EISSN:
1478-3231
ISSN:
1478-3223
Pubs id:
pubs:923702
URN:
uri:31dc89b5-7003-4f2a-b10b-0819d1f0e8ff
UUID:
uuid:31dc89b5-7003-4f2a-b10b-0819d1f0e8ff
Local pid:
pubs:923702

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