Background & Aims Oestrogen and oestrogen‐mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of hepatitis C virus life cycle is/are affected by oestrogens. Methods Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β‐estradiol (tested with/without its receptor antagonist fulvestrant). Dose–response c... Expand abstract
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- Liver International Journal website
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- Magri et al.
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Copyright © 2016 The Authors. Liver International Published by John Wiley & Sons Ltd.
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17,β‐estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle
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