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Norovirus GII.4 virus-like particles recognize galactosylceramides in domains of planar supported lipid bilayers.

Abstract:
A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

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Publisher copy:
10.1002/anie.201205972

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author


Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
51
Issue:
48
Pages:
12020-12024
Publication date:
2012-11-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851


Language:
English
Keywords:
Pubs id:
pubs:356269
UUID:
uuid:31d94d14-5103-4ed6-abd6-b4d0fbe57e19
Local pid:
pubs:356269
Source identifiers:
356269
Deposit date:
2013-11-16

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