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Norovirus GII.4 virus-like particles recognize galactosylceramides in domains of planar supported lipid bilayers.

Abstract:
A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

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Publisher copy:
10.1002/anie.201205972

Authors


Rydell, GE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
51
Issue:
48
Pages:
12020-12024
Publication date:
2012-11-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:31d94d14-5103-4ed6-abd6-b4d0fbe57e19
Source identifiers:
356269
Local pid:
pubs:356269

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