Journal article
AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination.
- Abstract:
- RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. One of the two major terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element. We show that homopolymer A/T tracts within the human β-globin CoTC-mediated terminator element play a critical role in Pol II termination. These short A/T tracts, dispersed within seemingly random sequences, are strong terminator elements, and bioinformatics analysis confirms the presence of such sequences in 70% of the putative terminator regions (PTRs) genome-wide.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.4MB, Terms of use)
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- Publisher copy:
- 10.1093/nar/gks1335
Authors
- Publisher:
- Oxford University Press
- Journal:
- Nucleic acids research More from this journal
- Volume:
- 41
- Issue:
- 3
- Pages:
- 1797-1806
- Publication date:
- 2013-02-01
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Language:
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English
- Keywords:
- Pubs id:
-
369834
- UUID:
-
uuid:31cd5546-c920-4e88-af28-426569ecbbf9
- Local pid:
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pubs:369834
- Source identifiers:
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369834
- Deposit date:
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2013-11-16
- ARK identifier:
Terms of use
- Copyright holder:
- White et al
- Copyright date:
- 2013
- Notes:
- Copyright © 2012 White et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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