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Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates

Abstract:

The most widely used task functional magnetic resonance imaging (fMRI) analyses use parametric statistical methods that depend on a variety of assumptions. In this work, we use real resting-state data and a total of 3 million random task group analyses to compute empirical familywise error rates for the fMRI software packages SPM, FSL, and AFNI, as well as a nonparametric permutation method. For a nominal familywise error rate of 5%, the parametric statistical methods are shown to be conserva...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1602413113

Authors


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ORCID:
0000-0001-7061-7995
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
ORCID:
0000-0002-4516-5103
Knutsson, H More by this author
Wellcome Trust More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
113
Issue:
28
Pages:
7900-7905
Publication date:
2016-06-28
Acceptance date:
2016-05-17
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:908847
URN:
uri:31bdede9-0985-4308-a860-236750e7ccb9
UUID:
uuid:31bdede9-0985-4308-a860-236750e7ccb9
Local pid:
pubs:908847

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