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Influence of pH on the conformation and stability of mismatch base-pairs in DNA.

Abstract:

A series of self-complementary dodecanucleotide duplexes containing two symmetrically disposed mismatches have been studied by pH-dependent, ultraviolet light melting techniques. The results indicate that A.C, and C.C mismatches are strongly stabilized by protonation and that the degree of stabilization of the A.C mismatch depends greatly on the flanking bases. In one case, a duplex containing two A.C mismatches is more stable than the native sequence below pH 5.5. The G.A mismatch displays c...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Leonard, GA More by this author
Journal:
Journal of molecular biology
Volume:
212
Issue:
3
Pages:
437-440
Publication date:
1990-04-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:31af87d3-4b22-4ac3-8478-a72475d22ae7
Source identifiers:
400098
Local pid:
pubs:400098

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