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Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X rays: evidence for chromatin movement during repair.

Abstract:

DNA repair within the cell nucleus is a dynamic process involving a close interaction between repair proteins and chromatin structure. Recent studies have indicated a quantitative relationship between DNA double-strand break induction and histone H2AX phosphorylation. The dynamics of this process within individual cell nuclei is unknown. To address this, we have used a novel focused ultrasoft X-ray microprobe that is capable of inducing localized DNA damage within a subnuclear area of intact ...

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Publication status:
Published

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Publisher copy:
10.1667/rr3577.1

Authors


Schettino, G More by this author
Kashino, G More by this author
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Journal:
Radiation research
Volume:
166
Issue:
1 Pt 1
Pages:
31-38
Publication date:
2006-07-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:319012a8-ef76-4229-9ff1-c5e30efe2f94
Source identifiers:
130929
Local pid:
pubs:130929

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