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Journal article

Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron.

Abstract:

Transduction of cells with multiple genes, allowing their stable and co-ordinated expression, is difficult with the available methodologies. A method has been developed for expression of multiple gene products, as fusion proteins, from a single cistron. The encoded proteins are post-synthetically cleaved and processed into each of their constituent proteins as individual, biologically active factors. Specifically, linkers encoding cleavage sites for the Golgi expressed endoprotease, furin, ha...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301341

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Journal:
Gene therapy
Volume:
7
Issue:
23
Pages:
1979-1985
Publication date:
2000-12-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:317383e2-2ea2-40aa-b6dc-a984c424fd3a
Source identifiers:
466391
Local pid:
pubs:466391

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