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Interaction of five globin gene abnormalities in a Cambodian family.

Abstract:

Members of a Cambodian family with an undiagnosed hypochromic, microcytic anaemia were found by haemoglobin and DNA analysis to have five interacting globin gene abnormalities. One child has Hb E and typical Hb H disease, while his mother has the form of Hb H disease associated with Hb Constant Spring interacting with Hb E. Quantitation of Hbs E and A2 by globin chain separation and triton/urea gel electrophoresis support the concept that Hb H/Constant Spring disease is a more severe form of ...

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Publication status:
Published

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Authors


Simpkins, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Weatherall, DJ More by this author
Journal:
British journal of haematology
Volume:
63
Issue:
1
Pages:
7-15
Publication date:
1986-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:3157c4f8-f1b6-417c-8636-b558188ed265
Source identifiers:
53936
Local pid:
pubs:53936

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